Angiogenesis and acute myeloid leukemia

作者：Haouas Houda^*

来源：Hematology, 2014, 19(6): 311-323.

DOI：10.1179/1607845413Y.0000000139

• Acute leukemia
• Angiogenesis
• Diagnosis
• Prognosis

Background: Angiogenesis is a word of Greek origin, 'angeio' refers to blood vessel, and genesis refers to creation, meaning the generation of new blood vessels. This process is essential for vertebrate development and plays a key role in human diseases. Angiogenesis is generally understood to be essential for the growth and metastasis of solid tumors and is also important in acute myeloid leukemia (AML).
Methods: This review summarizes the essential features of physiological and tumoral angiogenesis and the methods used for their assessment.
Results: Technologies for evaluating angiogenesis in AML are discussed and the prognostic significance of angiogenic factors is considered in the context of optimizing treatment.
Conclusion: As acute myelogenous leukemia and endothelial cells depend on each other for survival and proliferation, therapy directed against several pro-angiogenic factors might help to enhance the AML outcome.

• 出版日期2014-9