科研之友
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摘要
The role of melatonin in haemostasis is insufficiently determined. The study is aimed to investigate the effects of melatonin and luzindole (MT1 and MT2 melatonin receptor inhibitor) on integral haemocoagulation parameters. The study was performed on 52 male Wistar rats, kept at 12/12 h natural regimen dark/light. The daily doses of melatonin 0.2 mg/kg b.m. and luzindole 0.4 mg/kg b.m. were applied twice daily subcutaneously for three consecutive days. The rats were distributed into four equal groups (n = 13) and were treated as follows: the first group (control group) by saline; the second group by melatonin; the third group by luzindole; and the fourth group by luzindole and an hour later by melatonin. The results indicate that melatonin significantly shortens the activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT) (p < 0.001). Luzindole applied alone elongates aPTT, PT and TT (p < 0.001), which probably is a result of a suppressed endogenous melatonin secretion. Melatonin applied after luzindole pretreatment to a great extent repeats the effect of separate luzindole application. The results of the study suggest melatonin is significantly involved in haemocoagulation regulation leading to a tendency of hypercoagulability. The effects observed are accomplished both by modulation of the intrinsic and the extrinsic coagulation pathways, as well as by influence on conversion of fibrinogen to fibrin.
- 出版日期2014
