Microevolution of Burkholderia pseudomallei during an Acute Infection

作者:Limmathurotsakul Direk*; Holden Matthew T G; Coupland Paul; Price Erin P; Chantratita Narisara; Wuthiekanun Vana****; Amornchai Premjit; Parkhill Julian; Peacock Sharon J
来源:Journal of Clinical Microbiology, 2014, 52(9): 3418-3421.
DOI:10.1128/JCM.01219-14

摘要

We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.

  • 出版日期2014-9