Association with TP53 codon 72 polymorphism and the risk of non-Hodgkin lymphoma

作者：Kim Hee Nam; Yu Li; Kim Nan Young; Lee Il Kwon; Kim Yeo Kyeoung; Yang Deok Hwan; Lee Je Jung; Shin Min Ho; Park Kyeong Soo; Choi Jin Su; Kim Hyeoung Joon^*

来源：American Journal of Hematology, 2010, 85(10): 822-824.

DOI：10.1002/ajh.21834

Polymorphism of TP53 Arg72Pro is associated with many different cancers [1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-control study (945 cases and 1,700 controls). The TP53 72 CC genotype was associated with increased risk of NHL (P=0.04) and diffuse large B-cell lymphoma (P=0.04). Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in Korea.

• 出版日期2010-10