Aortic Customize: An In Vivo Feasibility Study of a Percutaneous Technique for the Repair of Aortic Aneurysms Using Injectable Elastomer

作者：Bosman W M P F^*; Vlot J; van der Steenhoven T J; van den Berg O; Hamming J F; de Vries A C; Brom H L F; Jacobs M J

来源：European Journal of Vascular and Endovascular Surgery, 2010, 40(1): 65-70.

DOI：10.1016/j.ejvs.2010.02.019

• Abdominal aortic aneurysm
• Aneurysm-sac filling
• Endovascular aneurysm repair
• In vivo study
• Polydimethylsiloxane

Objective: This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model.
Design: Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created.
Material: The formulation used in the experiments consisted of a two-component addition-cure liquid-silicone formulation, based on vinyl-terminated polydimethylsiloxane (PDMS).
Methods: The concept of aneurysm-sac filling was tested in vivo in porcine experiments (n = 3).
Results: In vivo porcine experiments with the sac-filling application showed successful exclusion of the created aneurysms with patent lumens and absence of endoleaks. The aneurysms were excluded successfully in the in vivo model, injecting elastomer through a 7-French catheter, filling up the entire aneurysm sac.
Conclusions: These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.

• 出版日期2010-7