LINGO-1 and its role in CNS repair

作者：Mi Sha^*; Sandrock Alfred; Miller Robert H

来源：International Journal of Biochemistry & Cell Biology, 2008, 40(10): 1971-1978.

DOI：10.1016/j.biocel.2008.03.018

• LINGO-1. CNS diseases
• regeneration
• remyelination

LINGO-1 is selectively expressed in the CNS on both oligodendrocyte precursor cells (OPCs) and neurons. Its expression is developmentally regulated in the normal CNS, as well as up-regulated in human or rat models of neuropathologies. LINGO-I functions as a negative regulator of oligodendrocyte differentiation and myelination, neuronal survival and axonal regeneration. Across diverse animal CNS disease models, targeted LINGO-1 inhibition was found to promote neuron and oligodendrocyte survival, axon regeneration, oligodendrocyte differentiation, remyelination and improved functional recovery. The targeted inhibition of LINGO-1 therefore presents a novel therapeutic approach for the treatment of neurological diseases.

• 出版日期2008
• 单位Biogen Idec