Using magnetized water as a solvent for a green, catalyst-free, and efficient protocol for the synthesis of pyrano[2,3-c]pyrazoles and pyrano[4 %26apos;,3 %26apos;: 5,6]pyrazolo [2,3-d]pyrimidines

Bakherad Mohammad; Keivanloo Ali; Gholizadeh Mostafa; Doosti Rahele; Javanmardi Mohaddese

doi:10.1007/s11164-016-2680-y

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Using magnetized water as a solvent for a green, catalyst-free, and efficient protocol for the synthesis of pyrano[2,3-c]pyrazoles and pyrano[4 %26apos;,3 %26apos;: 5,6]pyrazolo [2,3-d]pyrimidines

作者：Bakherad Mohammad; Keivanloo Ali; Gholizadeh Mostafa; Doosti Rahele; Javanmardi Mohaddese

来源：Research on Chemical Intermediates, 2017, 43(2): 1013-1029.

DOI：10.1007/s11164-016-2680-y

摘要

A facile, eco-friendly, and highly efficient one-pot four-component protocol is demonstrated for the synthesis of the pyrano[2,3-c] pyrazole and pyrano[4',3':5,6] pyrazolo [2,3-d] pyrimidine derivatives using magnetized water as a new green solvent. Simplicity, short reaction time, high yield, easy work-up, and absence of hazardous organic solvents are the main advantages of this method.