Augmented ST-Segment Elevation During Recovery From Exercise Predicts Cardiac Events in Patients With Brugada Syndrome

作者：Makimoto Hisaki; Nakagawa Eiichiro; Takaki Hiroshi; Yamada Yuko; Okamura Hideo; Noda Takashi; Satomi Kazuhiro; Suyama Kazuhiro; Aihara Naohiko; Kurita Takashi; Kamakura Shiro; Shimizu Wataru^*

来源：Journal of the American College of Cardiology, 2010, 56(19): 1576-1584.

DOI：10.1016/j.jacc.2010.06.033

• Brugada syndrome
• exercise testing
• ST-segment elevation

Objectives The goal of this study was to evaluate the prevalence and the clinical significance of ST-segment elevation during recovery from exercise testing. Background During recovery from exercise testing, ST-segment elevation is reported in some patients with Brugada syndrome (BrS).
Methods Treadmill exercise testing was conducted for 93 patients (91 men), 46 +/- 14 years of age, with BrS (22 documented ventricular fibrillation, 35 syncope alone, and 36 asymptomatic); and for 102 healthy control subjects (97 men), 46 +/- 17 years of age. Patients were routinely followed up. The clinical end point was defined as the occurrence of sudden cardiac death, ventricular fibrillation, or sustained ventricular tachyarrhythmia.
Results Augmentation of ST-segment elevation >= 0.05 mV in V(1) to V(3) leads compared with baseline was observed at early recovery (1 to 4 min at recovery) in 34 BrS patients (37% [group 1]), but was not observed in the remaining 59 BrS patients (63% [group 2]) or in the 102 control subjects. During 76 +/- 38 months of follow-up, ventricular fibrillation occurred more frequently in group 1 (15 of 34, 44%) than in group 2 (10 of 59, 17%; p = 0.004). Multivariate Cox regression analysis showed that in addition to previous episodes of ventricular fibrillation (p = 0.005), augmentation of ST-segment elevation at early recovery was a significant and independent predictor for cardiac events (p = 0.007), especially among patients with history of syncope alone (6 of 12 [50%] in group 1 vs. 3 of 23 [13%] in group 2) and among asymptomatic patients (3 of 15 [20%] in group 1 vs. 0 of 21 [0%] in group 2).
Conclusions Augmentation of ST-segment elevation during recovery from exercise testing was specific in patients with BrS, and can be a predictor of poor prognosis, especially for patients with syncope alone and for asymptomatic patients.

• 出版日期2010-11-2