A novel sol-gel strategy to prepare temperature-sensitive hydrogel for encapsulation of protein

作者：Zhang JT; Huang SW; Zhuo RX^*

来源：Colloid and Polymer Science, 2005, 284(2): 209-213.

DOI：10.1007/s00396-005-1357-7

• hydrogel
• phase separation
• stimuli-sensitive polymers
• sol-gel

A novel sol-gel strategy was proposed to prepare temperature-sensitive hydrogel including the copolymerization of N-isopropylacrylamide and 3-methacryloxypropyl-trimethoxy silane and then the hydrolysis and condensation of the linear polymers through the sol-gel process under extra-mild conditions. Bovine serum albumin, as a model protein, was loaded into the hydrogel matrix to investigate the encapsulation and release properties. Experimental results indicated that the preparation conditions were valuable for the loading and release of biomacromolecules.

• 出版日期2005-11
• 单位武汉大学