A novel synthesis of (E)-3-methylthio-3-substituted arylamino-2-cyanoacrylates under microwave irradiation

作者：Ouyang G; Song B^*; Zhang HP; Yang S; Jin LH; Li QZ; Hu DY

来源：Molecules, 2005, 10(10): 1351-1357.

DOI：10.3390/10101351

• 2-cyanoacrylate
• aromatic amine
• aminopyridine
• microwave irradiation

A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% similar to 93.5%) in 30 minutes at 50 degrees C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.

• 出版日期2005-10
• 单位贵州大学