Adiposity, leptin and stress reactivity in humans

作者：Brydon Lena^*

来源：Biological Psychology, 2011, 86(2): 114-120.

DOI：10.1016/j.biopsycho.2010.02.010

• Psychological stress
• Adiposity
• Leptin
• Cytokines
• Cardiovascular reactivity

Evidence suggests that individuals who are more obese may be more responsive to stress. Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses to acute laboratory stress in 67 women. We predicted that individuals with greater adiposity and/or higher plasma leptin would be more stress-responsive. Adiposity was unrelated to cardiovascular or neuroendocrine stress reactivity. However, women with larger waists had greater stress-induced increases in plasma leptin and interleukin-1 receptorantagonist (IL-1 Ra). Similarly, women with higher basal leptin displayed greater stress-induced increases in heart rate and plasma interleukin-6, and larger decreases in heart rate variability and cardiac pre-ejection period. Heightened cardiovascular and inflammatory stress responses are predictive of future cardiovascular risk. Our findings suggest that the cytokines leptin and IL-1 Ra may play a role in the association between obesity, stress and cardiovascular health.

• 出版日期2011-2