Non-alcoholic fatty liver disease is associated with high prevalence of gastro-oesophageal reflux symptoms

作者：Miele Luca^*; Cammarota Giovanni; Vero Vittoria; Racco Simona; Cefalo Consuelo; Marrone Giuseppe; Pompili Maurizio; Rapaccini Gianlodovico; Bianco Alessandro; Landolfi Raffaele; Ga**arrini Antonio; Grieco Antonio

来源：Digestive and Liver Disease, 2012, 44(12): 1032-1036.

DOI：10.1016/j.dld.2012.08.005

• Fatty liver
• Gastro-oesophageal reflux
• GERD
• Heartburn
• NAFLD
• Regurgitation
• Steatosis
• Symptoms

Background: Gastro-oesophageal reflux symptoms are usually reported by patients with obesity and metabolic syndrome. Aim of this study was to assess the prevalence and clinical characteristics of gastro-oesophageal reflux symptoms in subjects with non-alcoholic fatty liver disease. %26lt;br%26gt;Methods: Cross-sectional, case-control study of 185 consecutive patients with non-alcoholic fatty liver disease and an age- and sex-matched control group of 112 healthy volunteers. Participants were interviewed with the aid of a previously validated questionnaire to assess lifestyle and reflux symptoms in the 3 months preceding enrolment. Odds ratios were determined before and after adjustment for body mass index, increased waist circumference, physical activity, metabolic syndrome and proton pump inhibitors and/or antiacid medication. %26lt;br%26gt;Results: The prevalence of heartburn and/or regurgitation and of at least one of gastro-oesophageal reflux symptoms was significantly higher in the non-alcoholic fatty liver disease group. Non-alcoholic fatty liver disease subjects were associated to higher prevalence of heartburn (adjusted odds ratios: 2.17, 95% confidence intervals: 1.16-4.04), regurgitation (adjusted odds ratios: 2.61,95% confidence intervals: 1.24-5.48) and belching (adjusted odds ratios: 2.01,95% confidence intervals: 1.12-3.59) and had higher prevalence of at least one GER symptom (adjusted odds ratios: 3.34,95% confidence intervals: 1.76-6.36). %26lt;br%26gt;Conclusion: Non-alcoholic fatty liver disease is associated with a higher prevalence of gastro-oesophageal reflux symptoms.

• 出版日期2012-12