Neurotoxicity of acrylonitrile evaluated by manganese enhanced magnetic resonance imaging

作者：Li, Ying; Mei, Lihong; Qiang, Jinwei^*; Zee, Chi-Shing; Li, Xiuju; Liu, Junhua

来源：Molecular & Cellular Toxicology, 2015, 11(3): 367-372.

DOI：10.1007/s13273-015-0037-z

• Acrylonitrile
• Brain lesions
• Oxidative damage
• Pollutant
• Non-invasive method
• Manganese-enhanced magnetic resonance imaging

Acrylonitrile (ACN), a chemical compound commonly used to manufacture plastics, has been found in drin king water and as a pollutant in the air. Exposure to high levels of ACN leads to brain lesions via oxidative stress-induced injury. To date, there is no non-invasive method of examining brain lesions. We determined if manganese-enhanced magnetic resonance imaging (MEMRI) can be used to detect brain lesions in ACN-treated rats by exploiting the binding properties of manganese to the enzymes manganesesuperoxide dismutase (Mn-SOD) and glutamine synthetase (GS). Rats exposed to low, mid, and high doses of ACN over 7 days were subjected to MEMRI on the eighth day. Contrast enhancement of the brain decreased in ACN-treated rats, along with marked decreases in Mn-SoD and GS activities, particularly in mid- and high-ACN treated rats. Our study indicates that MEM-RI may be a potential non-invasive method of detecting ACN-induced oxidative damage.

• 出版日期2015-9
• 单位复旦大学