Antirotaviral Activity of Bovine and Ovine Dairy Byproducts

作者：Antonio Parron Jose; Ripolles Daniel; Dolores Perez Maria; Calvo Miguel; Trige Rasmussen Jan; Sanchez Lourdes^*

来源：Journal of Agricultural and Food Chemistry, 2017, 65(21): 4280-4288.

DOI：10.1021/acs.jafc7b01059

• antirotaviral activity
• dairy byproducts
• buttermilk
• butter serum
• milk fat globule membrane
• xanthine oxidase
• lactophorin
• cream washing
• heat treatment

Rotaviral gastroenteritis is associated with significant morbidity in developed countries and a high rate of infant mortality in developing countries. Diverse studies have demonstrated that a wide range of milk-derived fractions exhibit antirotaviral activity. The present study shows the antirotaviral activity of some bovine and ovine dairy byproducts, buttermilk, butter serum, and milk fat globule membrane (MFGM), and evaluates the effect of cream washing and heat treatment on that activity. Furthermore, the rotavirus-neutralizing activity was evaluated for some MFGM proteins, such as xanthine oxidase and lactophorin. Ovine and bovine buttermilk reached rota-virus-neutralizing values of 51.3 and 32.2%, at 1 mg/mL, respectively. The cream washing process led to a significant decrease in the antirotaviral activity of fractions. This activity was also influenced by heat treatment. Treatment at 75 degrees C for 20 s caused 24.6 and 36.1% decreases of activity in bovine and ovine buttermilk, respectively, and 85 degrees C for 10 min caused decreases of 80.9 and 79.0% in both fractions, respectively.

• 出版日期2017-5-31