A highly sensitive and rapidly responding fluorescent probe with a large Stokes shift for imaging intracellular hypochlorite

作者：Guo, Bingpeng; Nie, Hailiang; Yang, Wen; Tian, Yong; Jing, Jing^*; Zhang, Xiaoling^*

来源：Sensors and Actuators B: Chemical , 2016, 236: 459-465.

DOI：10.1016/j.snb.2016.06.004

• Fluorescent probe
• High sensitivity
• Specific
• Fast response
• Hypochlorite
• Large Stokes shift

A naphthalimide-based fluorescent probe NACl with a large Stokes shift has been successfully developed for highly sensitive, selective and ultrafast detection of hypochlorite (ClO-). This probe utilizes an oxidative deoximation reaction to provide high selectivity and optical dynamic range for detection of ClO- in aqueous solution. Compared to similar systems involving reactive oxygen species (ROS), including superoxide, tert-butyl hydroperoxide, hydroxyl radical, alkylperoxyl radical, and H2O2, NACl provides 138-fold fluorescence enhancement. Its outstanding response time of less than 3 s and detection limit of 2.88 nM establish the potential value of NACl for interrogating the pathology and physiology of intracellular endogenous ClO-.

• 出版日期2016-11-29
• 单位北京理工大学