Molecular signatures from paraffin-embedded specimens in breast cancer: the pathologist's viewpoint

作者：Dauplat M M^*; Penault Llorca F

来源：Oncologie, 2012, 14(9): 506-511.

DOI：10.1007/s10269-012-2202-5

• Breast cancer
• Microarrays
• Histopathology
• Prognosis
• Prediction
• Intrinsic classification

Oncology research, and particularly breast pathology, is undergoing a revolution with the advent of molecular signatures. These tools are complementary to the classical clinicopathological parameters commonly used in routine. The intrinsic signature brings, via a new taxonomy of breast cancer, a fresh look at the tumor beyond the histopathological type, grade and classic parameters of the tumor burden. Other prognostic signatures are MammaprintA (R), Oncotype DxA (R), and MapQant DxA (R). Some of these signatures are available for formalin-fixed paraffin-embedded tissues opening the door for an use in routine setting. However, pathological evaluation is still cornerstone for the optimal management of patients with breast cancer, with the back up of molecular signatures particularly for Hormone receptor positive, HER2 negative patients. Furthermore, true predictive signature are highly awaited.