Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice

作者：Okuyama Satoshi^*; Minami Sona; Shimada Naoko; Makihata Nahomi; Nakajima Mitsunari; Furukawa Yoshiko

来源：European Journal of Pharmacology, 2013, 699(1-3): 118-123.

DOI：10.1016/j.ejphar.2012.11.043

• Auraptene
• Global cerebral ischemia
• Hippocampus
• Anti-inflammation
• COX-2
• Neuroprotection

Cerebral ischemia causes delayed neuronal cell death in the hippocampus resulting in sequential cognitive impairments. Hyper-activated inflammation following ischemia is one of the etiologies for delayed neuronal cell death. In the present study, using a transient global ischemia mouse model, we showed that auraptene (AUR), a citrus coumarin, effectively inhibited microglia activation, cyclooxygenase-2 expression by astrocytes, and neuronal cell death in the hippocampus following ischemic insults. These results suggest that AUR acts as a neuroprotective agent in the ischemic brain, which may be mediated by suppression of the inflammatory response.

• 出版日期2013-1-15