An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

作者：Poon Chun Ting; Chan Pui Shan; Man Cornelia; Jiang Feng Lei; Wong Ricky Ngok Shun; Mak Nai Ki^*; Kwong Daniel W J; Tsao Sai Wah; Wong Wai Kwok

来源：Journal of Inorganic Biochemistry, 2010, 104(1): 62-70.

DOI：10.1016/j.jinorgbio.2009.10.004

• Porphyroid
• Two-photon
• Tumor-imaging
• Photodynamic therapy
• Ru(II)-polypyridyl

An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 +/- 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.

• 出版日期2010-1
• 单位香港浸会大学