Microparticles: a component of various diseases

作者：Budaj Miroslav^*; Poljak Zuzana; Duris Ivan; Kasko Martin; Imrich Richard; Kopani Martin; Maruscakova Lenka; Hulin Ivan

来源：Polish Archives of Internal Medicine-Polskie Archiwum Medycyny Wewnetrznej, 2012, 122(Suppl. 1): 24-29.

DOI：10.20452/pamw.1489

• cardiovascular disease
• cellular biology
• cellular interactions
• microparticles
• microvesicles

Microparticles (MPs) are phenotypically and functionally heterogeneous population of microvesicles. Although MP formation represents a physiological phenomenon. A multitude of pathologies, including inflammatory and autoimmune diseases, atherosclerosis, and malignancies, are associated with a considerable increase in circulating MPs. Elevated levels of platelet-, endothelial cell-, and monocyte-derived MPs have been documented in a number of clinical conditions in which vascular dysfunction and inflammation are important pathophysiological mechanisms (e. g., coronary artery disease or thrombotic microangiopathies). Knowledge of the functional properties of MPs will contribute to a better understanding of the pathological mechanisms of communication between cells and of the causes of various diseases.

• 出版日期2012