Do Patients with Non-Arteritic Ischemic Optic Neuritis Have Increased Risk for Cardiovascular and Cerebrovascular Events?

作者：Hasanreisoglu Murat; Robenshtok Eyal; Ezrahi David; Stiebel Kalish Hadas^*

来源：Neuroepidemiology, 2013, 40(3): 220-224.

DOI：10.1159/000342155

• Non-arteritic anterior ischemic optic neuropathy
• Myocardial infarction
• Cerebral vascular accident
• Diabetes
• Neuro-ophthalmology

Objectives: To compare the incidence of cardiac and cerebrovascular events following non-arteritic anterior ischemic optic neuropathy (NAION) compared to published control data using the Framingham, United Kingdom Prospective Diabetes Study (UKPDS) and the National Vascular Disease Prevention Alliance (NVDPA) data. Methods: A retrospective study of all consecutive cases of NAION between 1990 and 2005. Patients were stratified into those with or without prior ischemic events and into diabetics and non-diabetics. Outcome measures included cardiovascular morbidity, cerebrovascular events and the Framingham, UKPDS and NVDPA scores for each patient. Results: According to the NVDPA, the average absolute 5-year risk for cardiovascular disease (CVD) was 8.98, compared to 9 CVD events in our study. In the diabetic patients, 5 (17%) had a cardiac event and 2 (8%) had a cerebral vascular accident (CVA). Based on the UKPDS risk calculator, the average 10-year risk for cardiac events is 21.6%, CVA -6.8%. In the non-diabetics, there were 3 cases (7.5%) of myocardial infarction, compared to the average 10-year Framingham risk for myocardial infarction or coronary death of 11% (+/- 8 SD). Conclusions: Following NAION, the incidence of cardiovascular or cerebrovascular events in patients taking aspirin is not in major excess from that expected in risk-factor age-matched controls.

• 出版日期2013