科研之友
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摘要
Vernonia cinerea Less. (Asteraceae) is a herbaceous plant commonly found in SE Asia. Different parts of V. cinerea have been used in various folklore medicine applications, including reducing inflammation and detoxification. This study investigates the effects of V cinerea methanolic extract on the mouse immune system in vitro. Cytokine detection of ConA-stimulated splenocytes using ELISA, mitogen-induced splenocyte proliferation, and phagocytic activity were assayed. The results show that the extract shifted the Th1/Th2 balance towards a Th2 type response. Additionally, Th1- and Th2-related cytokine production correlated with lymphocyte proliferation by selective activation of T-cells into Th2-cells and suppression of Th1-cell proliferation. Our results confirmed the traditional applications of V. cinerea on immune-related remedies and anti-inflammation, suggesting a potential therapeutic application of this plant in the treatment of diseases associated with Th1-related cytokine production and inflammation.
- 出版日期2015-12
