1H-1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation

作者：Singh Amandeep; Biot Christophe; Viljoen Albertus; Dupont Christian; Kremer Laurent; Kumar Kewal; Kumar Vipan^*

来源：Chemical Biology & Drug Design, 2017, 89(6): 856-861.

DOI：10.1111/cbdd.12908

• antitubercular activity
• azide-alkyne cycloaddition reaction
• structure-activity relationship
• uracil-ferrocenylchalcones conjugates

Copper-catalyzed azide-alkyne [3 + 2] cycloaddition has been utilized for preparing a series of 1H-1,2,3-triazoles with the purpose of probing structure-activity relationships among a uracil-ferrocene-triazole conjugate family. The antitubercular evaluation studies revealed an improvement in activity with the introduction of a ferrocene nucleus among N-alkylazido-uracil precursors, with a preference for a bromo-substituent along with moderate chain lengths of n = 2-6. The reported protocol is a successful approach for integrating uracil-ferrocene-chalcone functionalities tethered via 1H-1,2,3-triazole rings with apparent physicochemical stability.

• 出版日期2017-6