A Case of Oxalate Nephropathy: When a Single Cause Is Not Crystal Clear

作者：Marques Sofia^*; Santos Sofia; Fremin Kimberly; Fogo Agnes B

来源：American Journal of Kidney Diseases, 2017, 70(5): 722-724.

DOI：10.1053/j.ajkd.2017.05.022

• Oxalate nephropathy
• acute kidney injury (AKI)
• kidney failure
• ascorbic acid
• vitamin C
• calcium oxalate
• hyperoxaluria
• EDTA
• kidney biopsy
• acute tubular injury
• case report

Hyperoxaluria can result in oxalate nephropathy with intratubular calcium oxalate crystallization and acute tubular injury. Primary inherited enzymatic deficiency or secondary causes such as excessive dietary intake, enteric increased absorption, or high doses of vitamin C, which is metabolized to oxalate, may underlie hyperoxaluria and oxalate nephropathy. We report a case of acute kidney injury due to oxalate nephropathy in a patient using chelating therapy with oral ethylenediamine tetra acetic acid (EDTA), intravenous supplementation with vitamin C, and chronic diarrhea and discuss the potential kidney damage these factors can cause in particular settings. To our knowledge, this is the first report suggesting an association between oral EDTA and oxalate nephropathy.

• 出版日期2017-11