Diagnostic performance of a semiconductor gamma-camera system as studied by multicenter registry

作者：Chikamori Taishiro^*; Goto Kenji; Hida Satoshi; Miyagawa Masao; Ishimura Hayato; Uchida Kenji; Fukuyama Takaya; Mochizuki Teruhito; Yamashina Akira

来源：Journal of Cardiology, 2017, 69(1-2): 449-455.

DOI：10.1016/j.jjcc.2016.02.020

• Cadmium-zinc-telluride camera
• Coronary artery disease
• Coronary angiography
• Single-photon emission computed
• tomography
• Diagnosis

Background: Despite the introduction of the novel cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) in Japan; its diagnostic value in clinical practice remains largely unknown.
Methods: The Semiconductor SPECT Study group is a multicenter Japanese registry which registered 1000 patients to evaluate the diagnostic utility of the CZT camera system (Discovery NM530c; GE Healthcare, Haifa, Israel). The patients underwent stress myocardial SPECT and coronary angiography within a 3-month interval. A significant stenosis was defined as >= 75% diameter narrowing based on the American Heart Association classification.
Results: Technetium (Tc-99m) radiotracer (555-1110 MBq) was used in 71% and thallium-201((201)T1) (74148 MBq) in 29%. The scan times with Tc-99m-radiotracer were 5-10 min for stress and 3-10 min for rest, whereas those with (201)T1 were 5-9 min for stress and 8-10 min for rest. To detect individual coronary stenosis, the respective sensitivities, specificities, and accuracies were 74%, 85%, and 81% for left anterior descending coronary artery (LAD) stenosis, 76%, 89%, and 85% for left circumflex stenosis, and 72%, 86%, and 82% for right coronary artery stenosis. However, 66% sensitivity and 91% specificity for LAD stenosis were observed with 99(m)Tc-radiotracer, whereas 88% sensitivity and 63% specificity were found with (201)T1.
Conclusions: The novel CZT SPECT system facilitated a short scan time with reduced radiotracer dose, yielding an acceptable diagnostic performance for angiographical coronary artery disease, although the low sensitivity for LAD detection with Tc-99m-radiotracer needs to be refined.

• 出版日期2017-2