Antibacterial activity of selected metabolites from Chilean lichen species against methicillin-resistant staphylococci

作者:Celenza Giuseppe*; Segatore Bernardetta; Setacci Domenico; Perilli Mariagrazia; Brisdelli Fabrizia; Bellio Pierangelo; Piovano Marisa; Garbarino Juan A; Amicosante Gianfranco; Nicoletti Marcello
来源:Natural Product Research, 2013, 27(17): 1528-1531.
DOI:10.1080/14786419.2012.730043

摘要

The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mu gmL(-1) for sphaerophorin to 1024 mu gmL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.

  • 出版日期2013-9-1