科研之友
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摘要
Acetylation of D-glucosamine catalysed by sulfuric acid and N-phthaloylation of the glucosyl acetate yielded 1,3,4,6-tetra- O-acetyl-2-deoxy-2-phthalimido-alpha-D-glucopyranose. This gave the corresponding pure beta-glucosyl chloride upon treatment with PCl5-BF3. An anomeric chlorination with thionyl chloride combined with the Lewis acids (ZnCl2, SnCl4 and BiCl3) resulted in an alpha/beta anomer mixture.
