A newly developed silymarin nanoformulation as a potential antidiabetic agent in experimental diabetes

作者：El Far Yousra M; Zakaria Mahmoud M; Gabr Mahmoud M; El Gayar Amal M; El Sherbiny Ibrahim M^*; Eissa Laila A

来源：Nanomedicine, 2016, 11(19): 2581-2602.

DOI：10.2217/nnm-2016-0204

• diabetes
• GSH
• insulin
• MDA
• Nkx6.1
• Pdx-1
• silymarin-loaded pluronic nanoparticles
• silymarin
• SOD
• STZ

Aim: This study aimed to develop a new stable nanoformulation of silymarin (SM) with optimum enhanced oral bioavailability and to evaluate its effect as well as mechanism of action as a superior antidiabetic agent over native SM using streptozotocin-induced diabetic rats. Materials and methods: SM-loaded pluronic nanomicelles (SMnp) were prepared and fully characterized. Biochemical parameters were performed as well as histological, confocal and reverse-transcription polymerase chain reaction studies on pancreatic target tissues. Results & conclusion: SMnp were found to improve significantly the antihyperglycemic, antioxidant and antihyperlipidemic properties as compared with native SM. In addition, SMnp was found to be a more efficient agent over SM in the management of diabetes and its associated complications due to its superior bioavailability in vivo, and the controlled release profile of SM.

• 出版日期2016-10