Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages

作者:Liu Mengyang*; Maurer Barbara; Hermann Boris; Zabihian Behrooz; Sandrian Michelle G; Unterhuber Angelika; Baumann Bernhard; Zhang Edward Z; Beard Paul C; Weninger Wolfgang J; Drexler Wolfgang
来源:Biomedical Optics Express, 2014, 5(9): 3150-3159.
DOI:10.1364/BOE.5.003150

摘要

Chick embryos are an important animal model for biomedical studies. The visualization of chick embryos, however, is limited mostly to postmortem sectional imaging methods. In this work, we present a dual modality optical imaging system that combines swept-source optical coherence tomography and whole-body photoacoustic tomography, and apply it to image chick embryos at three different development stages. The explanted chick embryos were imaged in toto with complementary contrast from both optical scattering and optical absorption. The results serve as a prelude to the use of the dual modality system in longitudinal whole-body monitoring of chick embryos in ovo.

  • 出版日期2014-9-1