Asymmetric domino Michael-Henry reaction of 1,2-diones with nitroolefins catalyzed by a chiral bisoxazolidine-Ni(acac)(2) complex

作者：Liang Qian; He Junpeng; Ni Bukuo^*

来源：Tetrahedron: Asymmetry , 2014, 25(15): 1146-1149.

DOI：10.1016/j.tetasy.2014.06.011

The asymmetric domino Michael-Henry reaction of 1,2-cyclohexadione with nitroolefins catalyzed by chiral ligand bisoxazolidine 1 and Ni(acac)(2) has been developed. This process provided highly functionalized chiral bicycle[3,2,1] octane derivatives with the generation of four new stereogenic centers in high yields (76-99%), and with excellent enantioselectivities (up to 99%) and good diastereoselectivities (up to 9:1) under mild reaction conditions. The procedure presented is simple and makes this method suitable for practical use.

• 出版日期2014-8-15