Associations of the insulin level and insulin resistance with the severity of coronary artery ectasia

作者：Cao, Yajing; Yin, Hongjing; Yin, Hongshan^*; Jiang, Zhian; Wang, Tao; Chen, Tao

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(5): 4937-4942.

• Insulin
• coronary artery ectasia
• severity of lesions
• association

Objective: To investigate the roles of insulin in coronary artery ectasia (CAE) and the association of insulin with the severity of CAE. Methods: The participants with CAE (n=80) or coronary arteriosclerosis (n=80), or healthy controls (n=80) undergoing coronary angiography in our hospital from March 2015 to March 2017 were enrolled in the current study. The fasting insulin (FINS) levels and the homeostasis model assessment-insulin resistance (HOMA-IR) index were compared among the three groups, and Spearman correlation analysis was conducted for clarifying the association of the insulin level with the severity of CAE. The patients with CAE were stratified into subsets of insulin resistance and insulin sensitivity in accordance with HOMA-IR, and the two subsets of patients were compared in systolic blood pressure (SBP), diastolic blood pressure (DBP), FINS, triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), as well as the severity of CAE lesions. In addition, Spearman correlation analysis was made for exploring the relationship between the severity of CAE and the HOMA-IR. Results: The FINS and HOMA-IR levels in the patients with CAE were remarkably higher than those of the patients with coronary arteriosclerosis and healthy controls (both P<0.05). SBP, DBP, FINS, TG, TC and LDL-C were substantially higher, but HDL-C was lower in the CAE patients with insulin resistance than in those with insulin sensitivity (all P<0.05); big differences in the subtypes of CAE lesions were also observed between the CAE patients with insulin resistance and those with insulin sensitivity (P<0.001). On Spearman correlation analysis, the severity of CAE was positively correlated with HOMA-IR (r=0.73, P=0.001), the plasma insulin level was also positively correlated with the severity of CAE (r=0.69, P=0.002). Conclusion: Insulin might be associated with the onset of CAE and its severity, with higher insulin level indicating more severe CAE.

• 出版日期2018
• 单位河北医科大学