Multiple Endocrine Neoplasia Genetics and Clinical Management

作者：Norton Jeffrey A; Krampitz Geoffrey; Jensen Robert T

来源：Surgical Oncology Clinics of North America, 2015, 24(4): 795-+.

DOI：10.1016/j.soc.2015.06.008

• Endocrine neoplasia
• Genetics
• Clinical management
• Multiple endocrine neoplasia

Early diagnosis of multiple endocrine neoplasia (MEN) syndromes is critical for optimal clinical outcomes; before the MEN syndromes can be diagnosed, they must be suspected. Genetic testing for germline alterations in both the MEN type 1 (MEN1) gene and RET proto-oncogene is crucial to identifying those at risk in affected kindreds and directing timely surveillance and surgical therapy to those at greatest risk of potentially life-threatening neoplasia. Pancreatic, thymic, and bronchial neuroendocrine tumors are the leading cause of death in patients with MEN1 and should be aggressively considered by at least biannual computed tomography imaging.

• 出版日期2015-10
• 单位NIH