Noninvasive measurement of lower extremity muscle oxygen extraction fraction under cuff compression paradigm

作者：Wang, Chengyan; Zhang, Rui; Zhang, Xiaodong; Wang, He; Zhao, Kai; Jin, Lixin; Zhang, Jue^*; Wang, Xiaoying^*; Fang, Jing

来源：Journal of Magnetic Resonance Imaging, 2016, 43(5): 1148-1158.

DOI：10.1002/jmri.25074

• susceptibility
• skeletal muscle
• cuff compression
• oxygen extraction fraction
• near-infrared spectroscopy

BackgroundTo demonstrate the feasibility of using a susceptibility-based MRI technique with asymmetric spin-echo (ASE) sequence to assess the lower extremity muscle oxygen extraction fraction (OEF) alternations under cuff compression paradigm. @@@ MethodsApproved by the local institutional human study committee, nine healthy young volunteers participated in this study. All the ASE scans were conducted using a 3 Tesla clinical MRI scanner during resting state (pre), 1-3min (post1) and 3-5min (post2) after a pressure of 50 mmHg above individual systolic blood pressure imposed on the thigh. Moreover, near-infrared spectroscopy (NIRS) measurements were performed on the same day under the same cuff compression protocol to verify the accuracy of this susceptibility-based method. @@@ ResultsIn all volunteers, the mean MRI based OEF in gastrocnemius (GAS) muscle increased significantly from 0.280.02 (pre) to 0.31 +/- 0.03 (post1, P<0.05) and 0.31 +/- 0.03 (post2, P<0.05). In addition, mean OEF in soleus (SOL) muscle went up from 0.31 +/- 0.01 (pre) to 0.33 +/- 0.03 (post1, P=0.14) and 0.37 +/- 0.04 (post2, P<0.05). For comparison, NIRS measured 1-%HbO(2) (percentage of deoxyhemoglobin concentration within total hemoglobin) in GAS rose significantly from 0.29 +/- 0.03 (pre) to 0.31 +/- 0.04 (post1, P<0.05) and 0.31 +/- 0.04 (post2, P<0.05), which confirmed the accuracy of the MRI-based OEF. @@@ ConclusionThis susceptibility-based OEF quantification technique together with cuff compression paradigm could provide a noninvasive, quantifiable and effective tool for measuring skeletal muscle oxygenation. J. Magn. Reson. Imaging 2016;43:1148-1158.

• 出版日期2016-5
• 单位北京大学