Alpha interferon administration during structured interruptions of combination antiretroviral therapy in patients with chronic HIV-1 infection: INTERVAC ANRS 105 trial

作者：Boue Francois^*; Reynes Jacques; Rouzioux Christine; Emilie Dominique; Souala Faouzi; Tubiana Rolland; Goujard Cecile; Lancar Remi; Costagliola Dominique

来源：AIDS, 2011, 25(1): 115-118.

DOI：10.1097/QAD.0b013e328340a1e7

Interferon-alpha administration during structured treatment interruptions (STIs) was studied in a phase III trial. We randomized 168 chronically infected HIV undetectable under combined antiretroviral therapy patients to have three STIs with or without a-interferon. The number of patients who had to resume treatment during post-STI follow-up was not significantly different between the two arms. Patients with a low CD4 nadir and a high baseline HIV-DNA had a higher risk of treatment resumption in the interferon arm.

• 出版日期2011-1-2