Acute kidney injury according to pediatric RIFLE criteria is associated with negative outcomes after heart surgery in children

作者：dos Santos El Halal Michel Georges; Carvalho Paulo Roberto A

来源：Pediatric Nephrology, 2013, 28(8): 1307-1314.

DOI：10.1007/s00467-013-2495-7

• Cardiac surgical procedures
• Acute kidney injury
• Child
• Intensive care units
• Mortality
• Renal insufficiency

Background The aim of this study was to investigate the association between the occurrence of acute kidney injury (AKI) according to pediatric RIFLE (pRIFLE) criteria and adverse outcomes in children after heart surgery.
Methods Children undergoing heart surgery in a tertiary hospital in Southern Brazil were followed during their stay in the pediatric intensive care unit (PICU) or until death. The exposure variable was occurrence of AKI according to pRIFLE criteria which place AKI in three categories: R (risk), I (injury), and F (failure). The outcomes studied were death, length of mechanical ventilation (MV), and length of PICU stay.
Results Eighty-five children were enrolled in the study. Of these, 47 (55.3 %) did not have AKI, while 22 (25.9 %), seven (8.2 %), and nine (10.6 %) were classified into pRIFLE categories R, I, and F, respectively. The incidence of death was 18.4 and 4.2 % in patients with and without AKI, respectively. Compared to children who did not develop AKI, the adjusted odds ratio for death was 1.05 [95 % confidence interval (CI) 0.09-11.11], 8.36 (95 % CI 1.32-52.63), and 7.85 (95 % CI 1.53-40.29) in the R, I, and F groups, respectively (p=0.022). Duration of MV and of PICU stay were significantly higher in those children with AKI.
Conclusions The occurrence of AKI according to pRIFLE criteria is associated to adverse outcomes in children after heart surgery.

• 出版日期2013-8