Association between 894G > T Endothelial Nitric Oxide Synthase Gene Polymorphisms and Metabolic Syndrome

作者：Escobar Piccoli Jacqueline C; Valle Gottlieb Maria Gabriela; Castro Luciano; Bodanese Luiz Carlos; Fernandes Manenti Euler Roberto; Bogo Mauricio Reis; Peres Alessandra; da Rocha Maria Izabel U M; Manica da Cruz Ivana Beatrice

来源：Arquivos Brasileiros de Endocrinologia e Metabologia, 2008, 52(8): 1367-1373.

• NOS3 polymorphism
• Nitric oxide synthase
• Metabolic syndrome
• Cardiovascular risk factors
• Metabolic disorder

Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type 11 diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT = 9.3%, GG = 37.2 and TG = 53.6% and the allelic frequencies were T=0.36 and G=0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist. (Arq Bras Endocrinol Metab 2008; 52/8:1367-1373)

• 出版日期2008-11