Nanoprecipitation for Poorly Water-Soluble Drugs

作者：Nguyen Tuong N G; Van Thanh Tran; Duan Wei; Tran Phuong H L; Tran Thao T D

来源：Current Drug Metabolism, 2017, 18(11): 1000-1015.

DOI：10.2174/1389200218666171004112122

• Nanoprecipitation
• poorly water-soluble drug
• solvent removal technique
• surfactant
• anti-solvent
• nanoparticulate

Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.
Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.
Results: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the anti-solvent. Second, the particle growth needs to be adjusted by surfactant addition.
Conclusion: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.

• 出版日期2017