Diversity-Oriented Synthesis of Spiropyrazolone-Based Tetrahydropyrroles via Three-Component 1,3-Dipolar Cycloadditions

作者：Wu, Qiong^*; Ma, Chun; Du, Xi-Hua; Chen, Yan; Cai, Pei-Jun^*

来源：Synthesis (Germany), 2016, 48(4): 595-605.

DOI：10.1055/s-0035-1560966

• 1
• 3-dipolar cycloaddition
• spiropyrazolone
• structural diversity

A highly efficient method for the synthesis of spiropyrazolone derivatives with structural diversity has been established via a facile three-component 1,3-dipolar cycloaddition of aldehydes, amino ester, and unsaturated pyrazolones. This protocol is applicable to a variety of unsaturated pyrazolones and aldehyde-derived azomethine ylides, providing an easy access to spiropyrazolone-based tetrahydropyrroles with structural diversity in high yields (up to 97%).

• 出版日期2016-2
• 单位中国矿业大学（北京）; 徐州工程学院