High-Dose Antiangiogenic Therapy for Glioblastoma: Less May Be More.?

作者:de Groot John F*
来源:Clinical Cancer Research, 2011, 17(19): 6109-6111.
DOI:10.1158/1078-0432.CCR-11-1853

摘要

Targeting angiogenesis in glioblastoma rapidly reduces vascular permeability and contrast enhancement on MRI and prolongs progression-free survival. The long-term efficacy of bevacizumab and other anti-angiogenic agents is limited, however, because of the rapid development of resistance. Alternative dosing approaches may be one mechanism of prolonging therapeutic efficacy. Clin Cancer Res; 17(19); 6109-11.

  • 出版日期2011-10-1