Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms

作者：Liu Runhui; Chen Xinyu; Falk Shaun P; Masters Kristyn S; Wei**lum Bernard; Gellman Samuel H^*

来源：Journal of the American Chemical Society, 2015, 137(6): 2183-2186.

DOI：10.1021/ja512567y

Candida albicans is the most common fungal pathogen in humans, and most diseases produced by C. albicans are associated with biofilms. We previously developed nylon-3 polymers with potent activity against planktonic C. albicans and excellent C. albicans versus mammalian cell selectivity. Here we show that these nylon-3 polymers have strong and selective activity against drug-resistant C. albicans in biofilms, as manifested by inhibition of biofilm formation and by killing of C. albicans in mature biofilms. The best nylon-3 polymer (poly-beta NM) is superior to the antifungal drug fluconazole for all three strains examined. This polymer is slightly less effective than amphotericin B (AmpB) for two strains, but the polymer is superior against an AmpB-resistant strain.

• 出版日期2015-2-18