Up-regulation of the vitamin C transporter SVCT2 upon differentiation and depolarization of myotubes

作者：Low Marcela; Sandoval Daniel; Morales Bryan; Nualart Francisco; Pablo Henriquez Juan

来源：FEBS Letters, 2011, 585(2): 390-396.

DOI：10.1016/j.febslet.2010.12.020

• Sodium-vitamin C co-transporter 2
• Ascorbate
• Myogenesis
• Fiber-type
• Skeletal muscle
• Depolarization

In addition to its role as a strong antioxidant, vitamin C regulates the differentiation of several cell lineages. In vertebrate skeletal muscle, the vitamin C transporter SVCT2 is preferentially expressed in slow muscle fibers. To gain insights into the possible involvement of intracellular vitamin C on early myogenesis, we investigated the regulation of SVCT2 expression in cultures of chick fetal myoblasts. SVCT2 expression increases in cultures of both, slow and fast muscle-derived myoblasts, as they fuse to form mainly fast myotubes. Interestingly, we found that SVCT2 could be positively modulated by potassium-induced depolarization of myotubes. These findings suggest that SVCT2-mediated uptake of vitamin C could play diverse roles on skeletal muscle development and physiology.

• 出版日期2011-1-21