Apical potassium (BK) channels and enhanced potassium secretion in human colon

作者:Sandle G I*; Hunter M
来源:QJM-An International Journal of Medicine, 2010, 103(2): 85-89.
DOI:10.1093/qjmed/hcp159

摘要

The human colon has the capacity to secrete potassium (K(+)) ions and enhanced K(+) secretion is a feature of a variety of diarrhoeal diseases. Recent work points to K(+) secretion in human colon being mediated by high conductance (BK) K(+) channels located in the apical membrane of colonic epithelial cells. The aim of this review is to highlight the importance of these channels in maintaining K(+) homoeostasis in health and disease.

  • 出版日期2010-2