Alteration of Warfarin's Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

作者：Tolstikov Tatjana G; Khvostov Mikhail V^*; Lifshits Galina I; Dushkin Alexander V; Meteleva Elezaveta S

来源：Letters in Drug Design and Discovery, 2011, 8(3): 201-204.

• Arabinogalactan
• Clathration
• Glycyrrhizic acid
• Warfarin

The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacon's anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).

• 出版日期2011-3