Neurogenesis and epilepsy

作者：Parent Jack M^*; Kron Michelle M

来源：Epilepsia, 2010, 51: 45-45.

DOI：10.1111/j.1528-1167.2010.02831.x

• Basal dendrites
• Dentate granule cells
• Dispersion
• Medial temporal lobe epilepsy
• Neural stem cells
• Seizures
• Sprouting
• Valproic acid

P>Persistent neural stem cells generate dentate granule cells (DGCs) throughout life. Evidence suggests that aberrant neurogenesis contributes to epileptic structural abnormalities, but that normally integrating adult-born DGCs may restore inhibition. Current research focuses on how epileptogenic insults alter neurogenesis, and whether restoring normal neurogenesis will attenuate epilepsy or its comorbidities. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).

• 出版日期2010-12