Antioxidant activities of a new lignan and a neolignan from Saururus chinensis

作者：Lee WS; Baek YI; Kim JR; Cho KH; Sok DE; Jeong TS^*

来源：Bioorganic & Medicinal Chemistry Letters, 2004, 14(22): 5623-5628.

DOI：10.1016/j.bmcl.2004.08.054

• LDL-antioxidant

A new diarylbutane lignan, 2'-hydroxy dihydroguaiaretic acid (4), and a known 8-O-4'-type neolignan, machilin D (5), were isolated from the ethyl acetate extracts of the underground parts of Saururus chinensis. Compounds 4 and 5 exhibited low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substances (TBARS) assay (4: IC50 = 3.3 muM and 5: IC50 = 3.8 muM), the lag time of conjugated diene production, the relative electrophoretic mobility (REM) of ox-LDL, the apoB-100 fragmentation on copper-mediated LDL oxidation and the macrophage-mediated LDL oxidation, and radical DPPH scavenging activity.

• 出版日期2004-11-15