Selective Synthesis of 1-O-Alkyl(poly)glycerol Ethers by Catalytic Reductive Alkylation of Carboxylic Acids with a Recyclable Catalytic System

作者：Sutter Marc; Dayoub Wissam; Metay Estelle; Raoul Yann; Lemaire Marc^*

来源：Chemsuschem, 2012, 5(12): 2397-2409.

DOI：10.1002/cssc.201200447

• alkylation
• carboxylic acids
• heterogeneous catalysis
• palladium
• reduction

(Poly)glycerol monoethers were synthesized in good yield and selectivity by the catalytic reductive alkylation of glycerol, diglycerol, and triglycerol with readily available, cheap and/or bio-sourced carboxylic acids. The reaction was catalyzed by 1 mol?% of Pd/C under 50 bar H2 using an acid ion-exchange resin as a recyclable cocatalyst. The catalytic system was recycled several times, and a mechanism is proposed for this transformation.

• 出版日期2012