Stability-indicating methods for the analysis of ciprofloxacin in the presence of its acid induced degradation product: A comparative study

作者：Attia Khalid A M; Nassar Mohammed W I; E Zeiny Mohamed B; Serag Ahmed^*

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2016, 159: 219-222.

DOI：10.1016/j.saa.2016.01.056

• Ciprofloxacin
• Stability-indicating
• Ratio derivative
• Ratio difference
• Mean centering
• Dual wavelength

Four rapid, simple, accurate and precise spectrophotometric methods were used for the determination of ciprofloxacin in the presence of its acidic degradation product. The methods under study are ratio derivative, ratio difference, mean centering and dual wavelength. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of ciprofloxacin in quality-control laboratories.

• 出版日期2016-4-15