A novel Pd-catalyzed N-dealkylative carbonylation of tertiary amines for the preparation of amides

作者:Fang Tao; Gao Xu Hong; Tang Ri Yuan; Zhang Xing Guo; Deng Chen Liang*
来源:Chemical communications, 2014, 50(94): 14775-14777.
DOI:10.1039/c4cc07378a

摘要

A novel and convenient protocol for the formation of amides via palladium-catalyzed N-dealkylative carbonylation of alkyl tertiary amines has been developed. In the presence of PdCl2(PhCN)(2), CuO, PhCN and CO, a range of substituents on both aryl iodides and alkyl tertiary amines were compatible with the reaction to afford a series of N,N-disubstituted amides in moderate to excellent yields.