mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas

作者：Suh Sunghwan; Kim Yun Hak; Goh Tae Sik^*; Jeong Dae Cheon; Lee Chi Seung; Jang Jeon Yeob; Cha Wonjae; Han Myoung Eun; Kim Seong Jang; Kim In Joo; Pak Kyoungjune^*

来源：Yonsei Medical Journal, 2018, 59(6): 746-753.

DOI：10.3349/ymj.2018.59.6.746

• Thyroid cancer
• SLC5A5
• fluorodeoxyglucose
• positron emission tomograph

Purpose: The present study investigated the dynamics and prognostic role of messenger RNA (mRNA) expression responsible for F-18-fluorodeoxyglucose (FDG) uptake in FDG positron emission tomography (PET) and radioactive iodine (I-131) uptake in whole-body radioactive iodine scans (WBS) in papillary thyroid cancer (PTC) patients.
Materials and Methods: The primary and processed data were downloaded from the Genomic Data Commons Data Portal. Expression data for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1-3), glucose-6-phosphate dehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1-4) mRNA were collected.
Results: Expression of SLC5A5 mRNA were negatively correlated with SLC2A1 mRNA and positively correlated with SLC2A4 mRNA. In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC without BRAF mutations. Expression of SLC5A5, SLC2A4, HK1, and G6PD mRNA was lower in PTC without BRAF mutation. PTCs with higher expression of SLC5A5 mRNA had more favorable disease-free survival, but no association with overall survival.
Conclusion: Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. 'I his finding provides a molecular basis for the management of PTC with negative WBS using F-18-FDG PET scans. In addition, higher expression of SLC5A5 mRNA was associated with less PTC recurrence, but not with deaths.

• 出版日期2018-8