Difluorohomologation of Ketones

作者:Kosobokov Mikhail D; Levin Vitalij V; Struchkova Marina I; Dilman Alexander D*
来源:Organic Letters, 2015, 17(3): 760-763.
DOI:10.1021/acs.orglett.5b00097

摘要

A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.

  • 出版日期2015-2-6