Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach

作者：Morgans Alicia K^*; van Bommel Annelotte C M; Stowell Caleb; Abrahm Janet L; Basch Ethan; Bekelman Justin E; Berry Donna L; Bossi Alberto; Davis Ian D; de Reijke Theo M; Denis Louis J; Evans Sue M; Fleshner Neil E; George Daniel J; Kiefert Jim; Lin Daniel W; Matthew Andrew G; McDermott Ray; Payne Heather; Roos Ian A G; Schrag Deborah; Steuber Thomas; Tombal Bertrand; van Basten Jean Paul; van der Hoeven Jacobus J M; Penson David F

来源：European Urology, 2015, 68(5): 891-898.

DOI：10.1016/j.eururo.2015.06.007

• Outcome assessment (health care)
• Patient-centered care
• Prostate cancer
• Quality indicators
• Health care
• Palliative care

Background: There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations.
Objective: We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care.
Design, setting, and participants: The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set.
Outcome measurements and statistical analysis: We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included.
Results and limitations: The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). Wedefined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control.
Conclusions: The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually.
Patient summary: Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer.

• 出版日期2015-11